Combinations of Interleukin-10 gene promoter polymorphisms with -1082A, -819T, -592A minor allele are associated with sinonasal polyposis
IL-10 gene in sinonasal polyposis
Sinonasal polyposis (SP) is an inflammatory disease involving multiple etiologies and pathogenesis. The disarray of Interleukin (IL)-10 is associated with a rised immunopathological response during the progression of many autoimmune diseases as well as the response to infection. We studied the possible role of the single nucleotide polymorphisms (SNPs) in IL-10 gene and their genotypic combinations in the SP pathogenesis. The IL-10’s promoter was genotyped in 200 participants (100 patients and 100 controls). The sites that were encompassed -1082, -819, and -592 SNP regions of extracted DNAs were analyzed by sequencing for polymorphisms. The IL-10 gene promoter polymorphisms with -1082A, -819T, -592A minor alleles, their heterozygotes and homozygotes mutant genotypes had signiﬁcantly higher risks for SP (P˂ 0.05). Also, haplotype analysis demonstrated that the GTC, ACC, and GCA haplotypes in IL-10 were high-risk of SP but ATA was only in controls (P= 0.007). Also the multifactor dimensionality reduction (MDR) analysis indicated that the IL-10-1082_-819 and -1082_-819_-592 were the best predictive models for SP with 66.6% and 69% accuracy, respectively. IL-10 genotypic variations and their combinations are linked with a high-risk for the SP development in the Turkish population. The IL-10 genetic polymorphisms may lend to SP by altering the arrangement of the gene expression, affecting the severity of the inflammatory response.
Sinonasal polyposis; IL-10 gene; Single nucleotide polymorphisms; Interaction; Multifactor dimensionality reduction
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