Investigation of Antibacterial and Cytotoxic Properties of Mix Ligand Complex of Zinc 2-Fluorobenzoate with Nicotinamide

  • Giray Bugra Akbaba Kafkas University, Department of Bioengineering, Kars, Turkey
  • Cem Ozturk Kafkas University, Department of Bioengineering, Kars, Turkey

Abstract

In this study, antibacterial properties of the previously synthesized zinc 2-f luorobenzo-ate with nicotinamide complex at 1.17; 2.33; 4.67; 9.34 and 18.67 mM concentrations was investigated using by agar well diffusion method against Bacillus subtilis, Psedomonasa eruginosa, Staphylococcus aureus, Escherichia coli, Bacillus cereus and Klebsiella pneumoniae bacterias. The MTT method was used to determine the cytotoxic properties of the complex on human peripheral blood cells at the same concentrations. According to the results of the antibacterial study, it was determined that the complex showed a good antibacterial effect on all bacteria at 18.67 and 9.34 mM concentrations. The complex exhibits to have a sup-pressive effect only on S. aureus bacteria at a concentration of 2.33 mM. It was observed that the complex was antibacterial on all bacteria except B. cereus and E. coli at a concentra-tion of 4.67 mM. The complex was found to have no growth inhibiting effect on any bac-teria at a concentration of 1.17 mM. The cytotoxicity of the complex was investigated by MTT test method and it was determined that the cell viability decreased due to increasing concentration according to the test results. Cell viability at 1.17; 2.33; 4.67; 9.34 and 18.67 mM was determined to be 86.20%, 86.05%, 72.87%, 64.77% and 6.42%, respectively.

Keywords:

Zinc complexes, Antibacterial activity, MTT, Cytotoxicity, Antibiotics.

DOI: 10.17350/HJSE19030000157

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Published
2019-12-31
How to Cite
Akbaba, G., & Ozturk, C. (2019). Investigation of Antibacterial and Cytotoxic Properties of Mix Ligand Complex of Zinc 2-Fluorobenzoate with Nicotinamide. Hittite Journal of Science & Engineering, 6(4), 269-274. Retrieved from https://www.hjse.hitit.edu.tr/hjse/index.php/HJSE/article/view/408
Section
SCIENCE